Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

Guirong Qu, Zhiguang Zhang, Haiming Guo, Mingwei Geng, Ran Xia
2007 Molecules  
A simple, rapid, and regioselective approach for the synthesis of N-(methoxycarbonylmethyl)-and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K 2 CO 3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
doi:10.3390/12030543 pmid:17851409 fatcat:lmsioi3llfhjnpthqr2y67o3qe