Alcoholism and smoking as a risk factor for late-onset Alzheimer's disease: A meta-analysis study

Mauro José Fontelles, Raimundo Miranda de Carvalho, Marcelo Silveira D'Oliveira
2007 Revista Paraense de Medicina  
RESUMO Objective: to determine, using a systematic review of meta-analysis studies, whether or not, remote alcohol and smoke are significant risk factors for late-onset Alzheimer's disease. Methods: using a meta-analysis statistics model, 12 case-control studies (6 for alcohol /6 for smoke) published on Medline from 1984 until 1999 which evaluated the interaction between those factors and Alzheimer's disease were investigated. Mantel-Haenszel adjusted odds ratio (OR) and 95% confidence
more » ... confidence intervals were calculated in stratified data. Epi Info statistical software was used to determine p-value with significant level at 0.05. Results: the studies showed that a prior history of alcohol abuse wasn't associated with late-onset of dementia due to Alzheimer's disease (OR=0.98; 95%CI 0.63 to 1.52;. And the other studies showed that a prior history of tabagism wasn't considered as a risk factor for AD (OR=0.70; 95%CI 0.57 to 0.85;. Conclusions: In this study alcoholism wasn't considered as a risk factor for AD .On the other hand , in people who had the smoke habit, chances of late-onset Alzheimer's development were reduced in 30%. In that case, tabagism was considered as a protector factor for AD.
doi:10.5123/s0101-59072007000100002 fatcat:axv3jzcuhfasbd3urm7qfzolgi