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Fail-safe genetic codes designed to intrinsically contain engineered organisms
2019
Nucleic Acids Research
One challenge in engineering organisms is taking responsibility for their behavior over many generations. Spontaneous mutations arising before or during use can impact heterologous genetic functions, disrupt system integration, or change organism phenotype. Here, we propose restructuring the genetic code itself such that point mutations in protein-coding sequences are selected against. Synthetic genetic systems so-encoded should fail more safely in response to most spontaneous mutations. We
doi:10.1093/nar/gkz745
pmid:31511890
pmcid:PMC6821295
fatcat:pmfsm6ol6zftfaljchbnjroru4