Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride

Mileni da Silva Fernandes, Flávia Godoy Iano, Vivian Rocia, Marcela Mitsuko Yanai, Aline de Lima Leite, Tatiana Almeida Furlani, Marília Afonso Rabelo Buzalaf, Rodrigo Cardoso de Oliveira
2011 Brazilian Archives of Biology and Technology  
The aim of this study was to compare the effect of fluoride (F) on alkaline phosphatase activity in the liver and plasma of the rats. Four groups of male Wistar rats (n=6), which received drinking water containing 5, 15 or 50 ppm F or deionized water (control) throughout the experiment were included in the study. The animals were euthanized and had their tissues and blood plasma collected for the analysis of fluoride and alkaline phosphatase. There was an increase in F concentration in most
more » ... tration in most tissues in the animals treated with higher F concentrations, except for the heart. The alkaline phosphatase assay showed an increase in the activity in the liver and blood plasma of the animals treated with fluoride concentrations of 15 and 50 ppm (p<0.05). This study suggested that F at a concentration of 50 ppm in drinking water promotes increased the activity of alkaline phosphatase in the liver and blood plasma.
doi:10.1590/s1516-89132011000600014 fatcat:s3zxmznjpnae5nfg6vrnygblha