X-Ray Studies on Phospholipid Bilayers. VIII. Interactions with Chlorpromazine · HCl

M. Suwalsky, L. Gimenez, V. Saenger, F. Neira
1988 Zeitschrift für Naturforschung C - A Journal of Biosciences  
Chlorpromazine is a widely used phenothiazine tranquilizer known to alter the shape of normal erythrocytes and their osmotic fragility. In order to understand the nature of the interactions chlorpromazine · HCl (CPZ · HCl) was made to interact with phospholipid bilayers formed by dimyristoylphosphatidylethanolamine (DMPE) and dimyristoylphosphatidylcholine (DMPC). This study was carried out by X-ray diffraction on crystalline powders of various molar mixtures of CPZ · HCl with DMPE and DMPC,
more » ... h DMPE and DMPC, with and without water. It was found that CPZ · HCl significatively affects the bilayer structure of DMPC in the presence of water, but not that of DMPE.
doi:10.1515/znc-1988-9-1018 fatcat:r7kyghjpqbh3jphcp3c5lpjrby