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The principles of good laboratory practice (GLP) have undergone little change since they were established 30 years ago. Conversely, there have been huge advances in science and technology during this time. Test facilities (TF) have been challenged to utilise these advancements and thus enhance the quality of their programmes of non-clinical safety testing. As a consequence, practices are very different today compared with the late 1970's. The scientific advancements have also extended thepmid:19351998 fatcat:xxpkrpcmajbshhmldurmiuwrka