Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women

S E Reis, S T Gloth, R S Blumenthal, J R Resar, H A Zacur, G Gerstenblith, J A Brinker
1994 Circulation  
Estrogen also attenuated abnormal coronary vasomotor responses to acetylcholine. Seven women who exhibited a paradoxical acetylcholine-induced decrease in coronary flow (-33.5±+ 12.3%, P<.01) and increase in resistance (38.9±14.1%, P=.05) and seven who had an abnormal acetylcholine-induced decrease in epicardial cross-sectional area (-14.2±4.4%; P=.04) did not have acetylcholineinduced changes in these parameters after EE administration. Acetylcholine-induced flow, resistance, and
more » ... , and cross-sectional area responses before and after EE were significantly different (P<.01, P=.02, and P=.02, respectively). Normal coronary responses to acetylcholine were not affected by EE administration. Conclusions EE attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. EE also decreases basal coronary vasomotor tone as manifested by increased coronary flow, decreased resistance, and increased epicardial cross-sectional area. These acute effects of estrogen on coronary vasoreactivity may explain, in part, the cardioprotective effects of estrogen in postmenopausal women. (Circulation. 1994;89:52-60.)
doi:10.1161/01.cir.89.1.52 pmid:8281693 fatcat:wukfeqebkvae5jp4amacfutqle