A New Alkaloid Glycoside from the Stems of Zanthoxylum dissitum Hemsl

Xian Wei, Yang Tan, Yuhe Shi, Yuan Yuan, Shunmin Li
2020 Records of Natural Products  
A new alkaloid glycoside (1) and six known alkaloids (2–7) were isolated from the stems of Zanthoxylum dissitum Hemsl.. The structure of compound 1 was resolved by spectrum data, including MS, IR, UV, and MS. All compounds obtained in this research were evaluated for their inhibitions against NO release from LPS-activated RAW264.7 macrophages. Compounds 1-3, 6 and 7 showed significant inhibition activities with IC50 values of 26.12±0.81, 8.41±0.23, 13.75±0.54, 6.97±0.77, and 5.78±0.42 μM,
more » ... 5.78±0.42 μM, respectively.
doi:10.25135/rnp. fatcat:mv7prvpygjhxpef7tsyiyqetrq