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Cone Precursor Cells Are the Cell-of-Origin in Retinoblastoma
2014
Cancer Discovery
Preserved Fulltext
RESEARCH WATCH Major finding: RB loss in human cone precursor cells promotes proliferation and retinoblastoma formation. Mechanism: NMYC, MDM2, p107, and SKP2-driven p27 degradation are required for proliferation after RB loss. Impact: Retinal cell-type-specific pathways render maturing cone precursors sensitive to RB depletion.
doi:10.1158/2159-8290.cd-rw2014-207
pmid:25367943
fatcat:zo4bqpnwgbd2bns7wa2gqbjgcq