Clinical Implication of Oct4 Expression in Squamous Cell Carcinoma of Lung

Tae-Jung Kim, Youn Soo Lee, Kyo-Young Lee, Chang Suk Kang
2010 The Korean Journal of Pathology  
: Octamer-4 (Oct4), a transcriptional factor involved in regulating embryonic stem cells, may play a role in tumorigenesis. Since little is known about the role of Oct4 as a prognostic factor for squamous cell carcinoma (SCC) of lung, we investigated its expression in SCC tissue and its clinicopathologic significance. Methods : Formalin-fixed, paraffin embedded tissues from 79 patients, including 44 complete resections and 35 biopsies, obtained from 1995 to 2008 were immunostained for Oct4,
more » ... ained for Oct4, scored, and scores correlated with clinicopathologic parameters and survival. Results : Oct4 expression in tumors was significantly associated with peripheral location (vs central location) (p = 0.004) and pleural invasion (p = 0.018). In 44 complete resections, survival analysis revealed that Oct4 expression and increased stage (II and III vs I) were significantly associated with worse survival in univariate analysis (p = 0.005 and p = 0.009, respectively) and in multivariate analysis (p = 0.024 and p = 0.033, respectively). Conclusions : The expression of Oct4 and high stage in SCC of lung are significant predictors of a poor prognosis and diminished overall survival.
doi:10.4132/koreanjpathol.2010.44.6.631 fatcat:keg4m353l5e4rdkfsejcgxoarq