Medetomidine- and Medetomidine-Ketamine-induced Immobilization in Blue Foxes (Alopex lagopus) and its Reversal by Atipamezole

Harry H. Jalanka
1990 Acta Veterinaria Scandinavica  
Jalanka, H.: Medetomidine-and medetomidine-ketamine-induced immobilization in bue foxes (Alopex liIgopusJ and its reversal by atipamezole. Acta vet. scand, 1990,31,63-71. -The sedativeand immobilizingeffects of the alphaj-adrenoceptor agonist medetomidinealone or combined with the dissociative anesthetic ketamine, were studied in blue foxes. Medetomidine at doses of 25 and 50 ug/kg induced moderate to deep sedation, but only with the highest medetomidinedose tested, 100 ug/kg , was the
more » ... ation complete. Medetomidine 50 ug/kg combined with ketamine 2.5 mg/kg rapidly induced complete immobilization, characterized by good rnyorelaxation , and no clinically significant alterations in serially determined hematologic and serum chemistry parameters. The alpha-adrenoceptor antagonist atipamezole effectively reversedthe medetomidine-or medetomidine-ketamine-induced immobilizations. A transient increase in heart rates was noted after each atipamezole injection. anesthesia ; alphaj-udr enocept or agonist, antagonist; hematology ; serum chemistry.
doi:10.1186/bf03547578 fatcat:532ptpz53rfxrfyia26gbjphn4