Antidiabetes Activity of Herbal Product Containing Phyllanthus niruri and Zingiber americans

Elfahmi Elfahmi, I Ketut Adnyana, Ika Fitria, Taufik Taufikurahman
2020 Sains Malaysiana  
state of hyperglycemia which usually accompanied by increasing blood glucose level. The combination of Phyllanthus niruri herbs and Zingiber americans rhizome has been produced as herbal medicine for the treatment of diabetes. The activity of herbal medicine product containing P. niruri and Z. americans in vivo. Antidiabetes activity was tested using oral glucose tolerance and alloxan induced methods. The blood glucose levels were measured in each experiment. In addition, the plasma
more » ... plasma triglyceride and total cholesterol levels were also measured. The results showed that the decrease of blood glucose levels on oral glucose tolerance method were 40.98, 44.84, and 47.02% at doses of 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control. While the decrease in blood glucose levels in alloxan induced method were 33.05, 38.82, and 41.79% at dose 90, 135, and 203 mg/kg BW, respectively (p <0.05) compared to control. The extract of dose 203 mg/kg BW appeared to be the most potent to decrease blood glucose levels in both methods, but did not show suppression activity of triglycerides and total cholesterol plasma. Suppression activities of serum triglycerides and total cholesterol were shown after treatment with the extract dose 90 and 135 mg/kg BW, which were each were 0.15, 0.16, and 1.85% w/w, respectively. ABSTRAK keadaan hiperglikemik yang diikuti dengan tingginya kadar gula dalam darah. Kombinasi tanaman herba Phyllanthud niruri dan Zingiber americans telah dijadikan sebagai produk ubat herba untuk mengubati penyakit diabetes. Kesan daripada gabungan dua tanaman ini masih berdasarkan kepada data empirik. Kajian ini dijalankan untuk membuktikan khasiat anti-diabetes daripada salah satu produk ubatan herba yang mengandungi P. niruri dan Z. americans secara in vivo. Kajian ke atas anti-diabetes ini dijalankan menggunakan kaedah induksi aloksan. Kandungan gula dalam darah untuk setiap percubaan dihitung. Selain itu, kadar trigliserids dan kolestrol juga diukur. Hasil menunjukkan bahawa kadar gula dalam darah dapat diturunkan dengan kaedah toleransi glukosa sebanyak 40.98, 44.84 dan 47.02% dengan dos 90, 135 dan 203 mg/kg BW (p < 0.05) berbanding kawalan. Penurunan dengan kaedah induksi aloksan pula adalah 33.05, 38.82 dan 42.79% pada dos 90, 135 dan 203 mg/kg BW (p < 0.05) berbanding kawalan. Ekstrak yang mengandungi dos 203 mg/kg BW menunjukkan penurunan kadar gula dalam darah paling tinggi dalam keduadua kaedah yang digunakan, namun tidak menunjukkan aktiviti penindasan trigliserids dan jumlah plasma kolestrol. Aktiviti penindasan serum trigliserids dan jumlah kolesterol dilihat selepas rawatan dengan ekstrak dos 90 dan 135 mg/kg BW sebanyak 0.15, 0.16 dan 1.85% w/w.
doi:10.17576/jsm-2020-4909-14 fatcat:y2msr3xoz5bcpj562uakmu64qi