Relationship Between Integrin β1 (ITGB1), β3 (ITGB3) and Intracerebral Hemorrhage (ICH) [post]

Hai-Yang Ma, Yan Xu, Chun-You Qiao, Yi Peng, Qi Ding, Li-Zhong Wang, Jun-Fei Yan, Yuan Hou, Fei Di
2020 unpublished
Background: Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes especially in low-grade patients. This study explored the relationship between expression of integrin β1 (ITGB1), β3 (ITGB3) in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. Methods: The expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC)
more » ... tochemical (IHC) staining and western blotting (WB) analysis, respectively. Results: Furthermore, the results demonstrated that TGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues.Conclusions: In summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.
doi:10.21203/rs.3.rs-45466/v1 fatcat:tkqpifawkzahzkczd5f4ndinee