Increased MMP2 contributes to the diagnosis and prognosis of lung cancer [post]

2020 unpublished
Matrix metalloproteinase 2 (MMP2) has been found to be correlated with the occurrence and development of lung cancer; the aim of this study was to investigate the clinical significance and prognosis value of MMP2 expression in lung cancer. Methods: The expression of MMP2 in lung cancer tissues was tested by immunohistochemistry and its serum level was tested by enzyme-linked immunosorbent assay. Results: The expression of MMP2 was higher in lung cancer tissues and serum of lung cancer patients,
more » ... ng cancer patients, and increased MMP2 was associated with tumor size, lymph node metastasis, advanced stage and postoperative survival time (p<0.05). The sensitivity and specificity of serum MMP2 for distinguishing lung cancer from lung benign diseases were 96.51% and 65.85%; and for distinguishing lung cancer from normal individuals were 97.67% and 75%. Conclusions: Increased serum MMP2 could be considered as a potential molecular biomarker for diagnosis and prognosis of lung cancer.
doi:10.21203/rs.2.20737/v1 fatcat:zajur3iyl5az3pkme5dlw6uezi