Alessandra Gianoncelli, Alberto Ongaro, Giuseppe Zagotto, Maurizio Memo, Giovanni Ribaudo
2020 Molbank  
On the basis of the knowledge from traditional herbal and folk medicine, flavonoids are among the most studied chemical classes of natural compounds for their potential activity as phosphodiesterase 5 (PDE5) inhibitors. We here describe the preparation of a semi-synthetic hydrazone derivative of quercetin, 2-(3,4-dihydroxyphenyl)-4-(2-(4-nitrophenyl)hydrazono)-4H-chromene-3,5,7-triol, that was obtained via a single-step modification of the natural compound. The product was characterized by NMR,
more » ... aracterized by NMR, mass spectrometry and HPLC. Preliminary molecular modeling studies suggest that this compound could efficiently interact with PDE5.
doi:10.3390/m1144 fatcat:m3i7lolgwjeerngvgfv47yiozu