Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment

Moses Kasembeli, Uddalak Bharadwaj, Prema Robinson, David Tweardy
2018 International Journal of Molecular Sciences  
Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of
more » ... STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.
doi:10.3390/ijms19082299 pmid:30081609 fatcat:aml7rwuq75flvgnbzsrkcxwt7q