Complexity across scales: a walkthrough to linking neuro-imaging readouts to molecular processes

Anandhi Iyappan, Sepehr Golriz Khatami, Martin Hofmann-Apitius
<span title="">2017</span> <i title="Open Access Text Pvt, Ltd."> <a target="_blank" rel="noopener" href="" style="color: black;">Journal of Systems and Integrative Neuroscience</a> </i> &nbsp;
Many histopathological studies have proposed that AD are often related to damage of specific cortical layers such as neocortex and entorhinal cortex [31,32]. The latest MRI techniques still are not capable of examining individual layers of the cortex. However, there are many semi-automated surface reconstruction tools such as FreeSurfer, 3D MPRAGE that aid in cortex examination [33][34][35]. Fractional anisotropy DTI techniques tracts the water diffusion in various tissues which provide vital
more &raquo; ... formation. They help in measuring the structure of white matter as well as fiber connectivity within and across brain regions [36][37][38]. Fractional anisotropy is a numerical measure of fiber integrity. This index is sensitive enough to detect the white matter degradation in aging and other neurodegenerative diseases [39][40][41] (Figure 1 ). Iyappan A (2017) Complexity across scales: a walkthrough to linking neuro-imaging readouts to molecular processes
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.15761/jsin.1000151</a> <a target="_blank" rel="external noopener" href="">fatcat:oomqcbhhrbgfjaobbrvn25lcnq</a> </span>
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