A Prospective Observational Study of Urinary Cytokines and Inflammatory Response in Patients With Overactive Bladder Syndrome [post]

Kiren Gill, Harry Horsley, Sheela Swamy, Rajvinder Khasriya, James Malone-Lee
2020 unpublished
Background Contemporary studies have discredited the methods used to exclude urinary tract infection (UTI) when treating overactive bladder (OAB). Thus we must revisit the OAB phenotype to check that UTI has not been overlooked.Aims To examine the differences in urinary cytokines IL6 and lactoferrin in OAB patients compared to controls, with references to microscopy of urine and enhanced quantitative urine culture.Methods A blinded, prospective cohort study with normal controls using six
more » ... ls using six repeated measures, achieved two-monthly, over 12 months.Results There were clinically significant between groups differences in urine IL6 (F =49.0, p<.001) and lactoferrin (F =228.5, p<.001). These differences were for lactoferrin correlated to symptoms (9.3, p=.003); for both to pyuria (IL6 F = 66.2, p<.001, Lactoferrin F=73.9, p<.001); and for IL6 microbial abundance (F = 5.1, P=.024). The pathological markers had been missed by urinary dipsticks and routine MSU culture.Conclusion The OAB phenotype may encompass patients with UTI that is being overlooked because of the failure of standard screening methods
doi:10.21203/rs.3.rs-116534/v1 fatcat:cgyth5npxjapdeiuuroyncy5he