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Functional Modulation of the Sodium Pump: The Regulatory Proteins "Fixit"
2003
Physiology
T he Na-K-ATPase is the integral membrane enzyme responsible for the active coupled transport of Na + and K + across the plasma membranes of animal cells. The enzyme is activated by the simultaneous presence of Na + and K + and is specifically inhibited by the plant glycoside ouabain. The generation and maintenance of the electrochemical gradients for Na + and K + requires energy that is derived from the hydrolysis of ATP, which in humans can amount to 25% of the basal metabolic rate. These
doi:10.1152/nips.01434.2003
pmid:12750449
fatcat:xxm3m33mvrarfecr7zqt32tfa4