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Recombination impacts damaging and disease mutation accumulation in human populations
MMany decades of theory have demonstrated that in non-recombining systems, slightly deleterious mutations accumulate non-reversibly1, potentially driving the extinction of many asexual species. Non-recombining chromosomes in sexual organisms are thought to have degenerated in a similar fashion2, however it is not clear the extent to which these processes operate along recombining chromosomes with highly variable rates of crossing over. Using high coverage sequencing data from over 1400doi:10.1101/006064 fatcat:qaus6pviafdrrbgsp6mur4ldxe