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Oral mucosal epithelia as other types of mucosal epithelia are known traditionally as protective tissues. In the present mini-review, attempts were made to introduce oral epithelia as non-lymphoid, non-myeloid tissue with immune potentials. Today, opinions holds the believe that oral epithelial cells have TLR system and can recognize microbial invaders. Microbial invaders in turn, induce epithelia to produce pro-inflammatory TH1, TH2 cytokines and Chemokines. The induction processes describeddoi:10.15406/ijvv.2016.02.00026 fatcat:ejuze75nhzfqzmtvgvn36rlt6e