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This study designs a low-voltage, label-free and fully integrated impedance-based biosensor using standard complementary metal oxide semiconductor (CMOS) technology to compute both capacitance and resistance of the electrode-electrolyte interface. The proposed biosensor circuit is composed of a commongate transimpedance amplifier (CG-TIA) with two quadrature phase Gilbert cell double-balanced mixers and finally integrated with microelectrode using 0.18 µm Silterra CMOS technology process. Thedoi:10.11113/jt.v67.2056 fatcat:xjkbdskkkvdc7l2ul7qnivbwri