Mycophenolate mofetil--a new atheropreventive drug?

Wioletta Olejarz, Dorota Bryk, Danuta Zapolska-Downar
Acta Poloniae Pharmaceutica - Drug Research  
Atherosclerosis is a form of chronic inflammation in which endothelial cell dysfunction, fibroproliferative process, oxidative stress and inflammatory cell activation are linked to plaque development and destabilization. T-lymphocytes also play a key role in pathogenesis of atherosclerosis. As a consequence, the suggested concept that modulation of an immunological response could be an appropriate target in the prevention of cardiovascular disease, is an important focus of research.
more » ... search. Mycophenolate mofetil (MMF) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH), that exerts anti-proliferative and pro-apototic effects, particularly on activated T-lymphocytes. MMF has other anti-atherogenic effects at the level of endothelial cells, monocytes/macrophages, smooth muscle cells and dendritic cells. In addition, MMF exhibits anti-oxidative properties. The present review paper provides an overview about the mechanisms of anti-atherosclerotic properties of MMF.
pmid:25265813 fatcat:xpcx5blx2fbirgl56oiikmlniq