Formulation and optimization of carbamazepine floating tablets

DM Patel, NM Patel, NN Pandya, PD Jogani
2007 Indian Journal of Pharmaceutical Sciences  
Patel, et al.: Carbamazapine Floating Tablets Floating tablets of carbamazepine were developed using melt granulation technique. Bees wax was used as a hydrophobic meltable material. Hydroxypropylmethylcellulose, sodium bicarbonate and ethyl cellulose were used as matrixing agent, gas-generating agent and fl oating enhancer, respectively. The tablets were evaluated for in vitro buoyancy and dissolution studies. A simplex lattice design was applied to investigate the combined effect of 3
more » ... effect of 3 formulation variables i.e. amount of hydroxypropyl methylcellulose (X 1 ), ethyl cellulose (X 2 ) and sodium bicarbonate (X 3 ). The fl oating lag time (F lag ), time required for 50% (t 50 ) and 80% drug dissolution (t 80 ) were taken as responses. Results of multiple regression analysis indicated that, low level of X 1 and X 2 , and high level of X 3 should be used to manufacture the tablet formulation with desired in vitro fl oating time and dissolution. Formulations developed using simplex lattice design were fi tted to various kinetic models for drug release. Formulation S3 was selected as a promising formulation and was found stable at 40 o and 75% relative humidity for 3 months. Present study demonstrates the use of simplex lattice design in the development of fl oating tablets with minimum experimentation.
doi:10.4103/0250-474x.39430 fatcat:wxggq4vjtzdlva7tdb6xzqkshy