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Chemogenomics knowledgebased polypharmacology analyses of drug abuse related G-protein coupled receptors and their ligands
2014
Frontiers in Pharmacology
† These authors have contributed equally to this work. Drug abuse (DA) and addiction is a complex illness, broadly viewed as a neurobiological impairment with genetic and environmental factors that influence its development and manifestation. Abused substances can disrupt the activity of neurons by interacting with many proteins, particularly G-protein coupled receptors (GPCRs). A few medicines that target the central nervous system (CNS) can also modulate DA related proteins, such as GPCRs,
doi:10.3389/fphar.2014.00003
pmid:24567719
pmcid:PMC3915241
fatcat:gzm2i2o4vfgltfszll65bwvml4