Low molecular weight heparin in intraocular infusion in high risk group cataract surgery - minimizes inflammatory reaction and prevents posterior capsular opacification
Journal of Medical Science And clinical Research
Aim: To evaluate the influence of heparin infusion with square edge IOL on postoperative inflammatory response and posterior capsular opacification. Methods: This randomized prospective study included 60 patients with high risk i.e. congenital traumatic, complicated, diabetic cataract and lens induced glaucoma. All cases had small incision cataract surgery with square edge IOL implantation. The cases were divided in two groups-Group A (study group), Group B (control group). Heparinized
... eparinized (40mg/500ml) infusion was used in 31 cases (group A). 29 cases (group B) were done without heparin infusion. The degree of postoperative inflammation was compared between two groups with slit lamp biomicroscopy. PCO was assessed subjectively at slit lamp with fully dilated pupil. Result: Group A revealed 0 to +1 anterior chamber reaction and mild to moderate surface deposition during early postoperative days. Groups B revealed +2 to +4 anterior chamber reaction and moderate to severe surface deposition during early postoperative days. The regenerating PCO was significantly higher in group B then group A. This reveals that use of heparin infusion during cataract surgery in high risk cases significantly reduces the anterior chamber reaction and postoperative inflammation related complications. Conclusion: In high risk cases heparin infusion with square edge IOL implantation has the advantage of being safe and is effective means of reducing postoperative inflammation and decreases PCO formation without significant side effects.