Meiotic disturbances related to human male sterility

J. M. LUCIANI, A. STAHL
1978 Reproduction nutrition development (Print)  
The authors found an abnormal karyotype in 5 to 15 p. 100 of the cases of male sterility studied. There was a close correlation between the frequency of chromosomic abnormalities and the degree of oligospermy. Most of these abnormalities concerned the sex chromosomes, but the frequency of some robertsonian and reciprocal translocations was higher than that of the general population. It was not known why a chromosomal abnormality altered spermatogenesis. The expression of these abnormalities,
more » ... e abnormalities, especially translocations, was very diversified, ranging from normal fertility to total sterility with severe oligospermy or azoospermy. In a small number of cases (about 5 p. 100), various meiotic abnormalities were found in sterile subjects with a normal somatic karyotype. These abnormalities were characterized by a high frequency of polyploid cells, related abnormalities and a smaller number of chiasmas, degeneration and a high frequency of univalent X and Y chromosomes during metaphase I. Although their origin was unknown, some abnormalities, chiasmatic in character, probably represented the first example of a meiotic mutant owing to an inbreeding factor in two azoospermic subjects. It has been well-established in the last few years that chromosomal anomalies are one cause of human male sterility. These anomalies act in different ways : -
doi:10.1051/rnd:19780307 fatcat:6oa5vztwznenfkpsc272x7ayka