Scalp high-frequency oscillation rates are higher in younger children

Dorottya Cserpan, Ece Boran, Santo Pietro Lo Biundo, Richard Rosch, Johannes Sarnthein, Georgia Ramantani
2021 Brain Communications  
High-frequency oscillations in scalp EEG are promising non-invasive biomarkers of epileptogenicity. However, it is unclear how high-frequency oscillations are impacted by age in the pediatric population. We prospectively recorded whole-night scalp EEG in 30 children and adolescents with focal or generalized epilepsy. We used an automated and clinically validated high-frequency oscillation detector to determine ripple rates (80-250 Hz) in bipolar channels. Children < 7 y had higher
more » ... ncy oscillation rates (p=0.021) when compared to older children. The median test-retest reliability of high-frequency oscillation rates reached 100% (iqr 50) for a data interval duration of 10 min. Scalp high-frequency oscillation frequency decreased with age (r=-0.558, p=0.002), whereas scalp high-frequency oscillation duration and amplitude were unaffected. The signal-to-noise ratio improved with age (r = 0.37, p=0.048), and the background ripple band activity decreased with age (r=-0.463, p=0.011). We characterize the relationship of scalp high-frequency oscillation features and age in pediatric patients. EEG intervals of ≥ 10 min duration are required for reliable measurements of high-frequency oscillation rates. This study is a further step towards establishing scalp high-frequency oscillations as a valid epileptogenicity biomarker in this vulnerable age group.
doi:10.1093/braincomms/fcab052 pmid:33870193 pmcid:PMC8042248 fatcat:ka675henanazll7bguvfej73aa