An Overview of Oxidative Stress, Neuroinflammation and Neurodegenerative Diseases

Daniel Mihai Teleanu, Adelina-Gabriela Niculescu, Iulia Ioana Lungu, Crina Ioana Radu, Oana Vladâcenco, Eugenia Roza, Bogdan Costăchescu, Alexandru Mihai Grumezescu, Raluca Ioana Teleanu
2022 International Journal of Molecular Sciences  
Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen species with the pathophysiology of Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Oxidative stress was also noted to modify the inflammatory response. Even though oxidative stress and
more » ... mation are two totally different pathological events, they are linked and affect one another. Nonetheless, there are still several mechanisms that need to be understood regarding the onset and the progress of neurodegenerative diseases in order to develop efficient therapies. As antioxidants are a means to alter oxidative stress and slow down the symptoms of these neurodegenerative diseases, the most common antioxidants, enzymatic as well as non-enzymatic, have been mentioned in this paper as therapeutic options for the discussed disorders.
doi:10.3390/ijms23115938 pmid:35682615 pmcid:PMC9180653 fatcat:7ujjpoeypvhmbfx2febhkic52y