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Biosynthesis and Function of the Coronavirus Spike Protein
[chapter]
1990
Advances in Experimental Medicine and Biology
One of the most interesting aspects of coronavirus replication is their intracellular assembly. Budding is localized in the ER-pre Golgi region (8, 26). Both coronavirus glycoproteins are synthesized in the RER on membrane bound ribosomes (16). The integral membrane protein (M) accumulates in the perinuclear region and is believed to determine the site of budding. The spike protein (S) mediates binding of virions to the host cell receptor, possesses a fusogenic activity and is the major target
doi:10.1007/978-1-4684-5823-7_3
fatcat:qxlu7xo7p5e7teoc2yhwh5dema