Clinical and biochemical aspects of development of bronchial obstruction in asthma

O. V. Kozina, V. V. Andrushkevich, A. E. Sazonov, I. V. Petrova, V. A. Egorov, E. V. Komyakova, N. N. Chusova, M. S. Yusubov, L. M. Ogorodova
2008 Russian Pulmonology  
The aim of this study was to investigate NO- and lipid peroxidation (LPO)-related airway reactivity and its correlation to ventilation disorders in different clinical variants of asthma. NO, malone dialdehyde, IL-4, TNF-α, and IgE were measured in BAL fluid and blood serum of 39 asthma patients and 15 healthy volunteers matched for age and gender.In patients with stable asthma, airflow parameters in small and medium airways were significantly decreased compared to those of healthy persons.
more » ... ntrations of key cytokines of atopic inflammation in BAL fluid and serum were increased in asthma patients. Serum IgE tended to decrease and IL-4 and TNF-α in BAL fluid increased in asthma patients while the disease worsened. Inverse correlations were found between NO and TNF-α, malone dialdehyde concentration and parameters of bronchial obstruction.In conclusion, NO production in airways is caused by strong accumulation of inflammatory cells with high metabolic activity resulting in release of inflammatory and pro-inflammatory cytokines which regulate immunopathological reagine-induced inflammation.
doi:10.18093/0869-0189-2008-0-2-52-57 fatcat:qzzvpmqa4fdk5cuh4o3lublova