Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population [post]

2020 unpublished
Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that variants in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and are associated with the risk of diseases. In the current study, we evaluated the influence of ERAP gene (ERAP1 and ERAP2) variants on susceptibility to cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: Six single nucleotide polymorphisms
more » ... Ps) in ERAP1 and 5 SNPs in ERAP2 were selected and genotyped in 556 CIN patients, 1072 cervical cancer patients, and 1262 healthy control individuals. Candidate SNPs
doi:10.21203/rs.2.21433/v2 fatcat:z5hjwbhgw5bnxkcsj636jhqawm