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Interaction of IGF-Binding Protein-Related Protein 1 with a Novel Protein, Neuroendocrine Differentiation Factor, Results in Neuroendocrine Differentiation of Prostate Cancer Cells
Journal of Clinical Endocrinology and Metabolism
Neuroendocrine cells have been implicated in many cancers, including small cell lung, cervical, breast, and prostate carcinomas. The increase in neuroendocrine cell number in prostate cancer has been reported to correlate with poor prognosis, progressive tumors, and androgen insensitivity. The mechanisms involved in this differentiation remain unknown. IGF-binding protein-related protein 1 is a member of the IGFbinding protein superfamily and has recently been shown to exhibit differentiationdoi:10.1210/jc.86.9.4504 pmid:11549700 fatcat:mu3paenj2vdjplzip2st3fu23i