BASIC DETERMINANTS OF MELANOMA STEM CELL

A. A. Vartanian, M. V. Oborotova
2015 Российский Биотерапевтический Журнал  
Melanoma is considered to be the deadliest form of skin cancer. For years it has been accepted that all melanoma cells in tumor are capable of tumor formation and each of them has the ability to initiate the metastasis. At present a stem cell theory of cancer has been developed, which purports that a subpopulation of self-renewing tumor cells is responsible for tumorogenesis, neoangiogenesis and stroma building. In this review we will discuss the basic determinants of melanoma stem cell and
more » ... a stem cell and melanoma stem cell targeting implications.
doi:10.17650/1726-9784-2015-14-2-7-16 fatcat:gwlk4x3i5bf2jecdriotpqo4fq