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Anti-CD20 monoclonal antibody has been successfully used to treat several self-immune diseases. The authors report the case of a 71 year-old female patient under the use of pegylated form of interferon á associated with ribavirin for the treatment of hepatitis C, who, after concluding the therapeutic program -negative Polymerase Chain Reaction (PCR) -developed a severe cutaneous vasculitis, receiving the diagnostic of type II mixed cryoglobulinemia. Four sessions of plasmapheresis weredoi:10.1590/s1413-86702007000100038 pmid:17625752 fatcat:a3f4mx6sgrdyhjraqwyxadleyy