A New Triterpene from the Plant of Uncaria Macrophylla

Guangli Sun, Xiaopo Zhang, Xudong Xu, Junshan Yang, Mingliang Zhong, Jingquan Yuan
2012 Molecules  
Our ongoing investigations on the stem bark of Uncaria macrophylla afforded a new ursolic triterpene, 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester (1), named uncariursanic acid, and three known ursolic triterpenes including 3β,6β,19α-trihydroxy-23-oxo-urs-12-en-28-oic acid (2), 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid (3) and ursolic acid (4). Their structures were elucidated by extensive spectral methods, including 1D and 2D NMR and HR-ESI-MS. The cytotoxicities
more » ... The cytotoxicities of the four compounds were evaluated against two cancer cell lines (MCF-7 and HepG2) by the MTT method, and only compound 4 exhibited potent activity.
doi:10.3390/molecules17010504 pmid:22222909 fatcat:mytauz2zwbacrc6enbdukv4syi