Immunoproliferative Small Intestinal Disease with Protein Loss Complicated with Duodenal T Cell Lymphoma during Progression

Takeshi Hara, Hisashi Tsurumi, Tomohiro Kato, Yasuyuki Imao, Yasushi Kojima, Keishi Kojima, Jun-ichi Kitagawa, Naoki Katsumura, Hiroshi Araki, Tsuyoshi Takami, Hisataka Moriwaki
2008 Internal medicine (Tokyo. 1992)  
A 52-year-old man was admitted to our hospital in October 2001 with abdominal pain. Abdominal X-ray indicated a diagnosis of ileus. Histopathological and immunological examination resulted in a diagnosis of immunoproliferative small intestinal disease (IPSID). He was treated with THP-COP therapy (pirarubicin, cyclophosphamide, vincristine, and prednisolone), which resulted in complete remission. Outpatient follow-up revealed hypoalbuminemia in May 2003 and upper gastrointestinal endoscopy
more » ... duodenal mucosal nodularity. He was diagnosed with relapsed IPSID and salvage chemotherapy was started. Follow-up endoscopy confirmed that the therapy was effective, but uncovered another duodenal mucosal nodularity. Immunohistochemical staining revealed T-cell lymphoma. Chemotherapy was discontinued and the patient died in December 2004.
doi:10.2169/internalmedicine.47.0524 pmid:18277034 fatcat:k33xd2u6izclpeh2f3tgam4fza