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A series of new thiosemicarbazones derived from natural diterpene kaurenoic acid were synthesized and tested against the epimastigote forms of Trypanosoma cruzi to evaluate their antitrypanosomal potential. Seven of the synthesized thiosemicarbazones were more active than kaurenoic acid with IC 50 values between 2-24.0 µM. The o-nitrobenzaldehyde-thiosemicarbazone derivative was the most active compound with IC 50 of 2.0 µM. The results show that the structural modifications accomplisheddoi:10.3390/molecules16021166 pmid:21270733 fatcat:72ty7kmblff63c7xgjts5wq5gy