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Studies on the Metabolic Fate of Felodipine. (V): Absorption, Distribution, Metabolism and Excretion after a Single Oral Administration to Dogs
1992
Drug Metabolism and Pharmacokinetics
3. In the plasma, the parent compound was a minor substance and M-III and M-IV were mainly found. In the urine, M-III, M-IV and M-V were the major metabolites , while in the feces, M-III, M-IV, M-VI (lactone) and M-VII (lactone) were mainly found. Hardly any sex difference was present in the relative amounts of metabolites in the plasma, urine and feces. The major metabolites UM1 and UM2 found in the plasma of rats were not present in the plasma of dogs.
doi:10.2133/dmpk.7.461
fatcat:dud6yohzevfizcg2iwv3embl5i