Studies on the Metabolic Fate of Felodipine. (V): Absorption, Distribution, Metabolism and Excretion after a Single Oral Administration to Dogs

Kazuo UNO, Satoru YAMAGAMI, Shigeru TABATA, Shuji KONDO, Yoshio ESUMI, Matsuo TAKAICHI, Yoshitaka JIN, Hisako ISHIKAWA, Sadao Tsuji
1992 Drug Metabolism and Pharmacokinetics  
3. In the plasma, the parent compound was a minor substance and M-III and M-IV were mainly found. In the urine, M-III, M-IV and M-V were the major metabolites , while in the feces, M-III, M-IV, M-VI (lactone) and M-VII (lactone) were mainly found. Hardly any sex difference was present in the relative amounts of metabolites in the plasma, urine and feces. The major metabolites UM1 and UM2 found in the plasma of rats were not present in the plasma of dogs.
doi:10.2133/dmpk.7.461 fatcat:dud6yohzevfizcg2iwv3embl5i