Prediction of Patient-Specific Tissue Engineering Scaffolds for Optimal Design

Yong L. Chuan, Md. E. Hoque, Ian Pashby
2013 International Journal of Modeling and Optimization  
The fabrication of patient-specific tissue engineering scaffold is highly appreciated that requires prior estimation of porous and mechanical characteristics. Architectural controllability and reproducibility are also essential aspects in the development of 3D functional scaffolds. This work presents a computational approach to determine porous and mechanical characteristics of 3D scaffolds. The computational modeling could be a powerful tool to assist designing 3D scaffold with optimum
more » ... ristics as required for a particular patient in need. The 3D scaffolds were successfully modeled investigating the influences of design parameters on the porous and mechanical properties via finite element analysis (FEA) and ANSYS application software. It was revealed by ANSYS that the increase in porosity decreased the mechanical properties and increased the damping factor. The Scaffold porosities were obtained in the range of 47% to 95% with varying pore shape and size by modulating lay-down pattern, filament diameter and filament distance. Index Terms-Tissue engineering, scaffold, rapid prototyping, finite element analysis.
doi:10.7763/ijmo.2013.v3.322 fatcat:paszmwszh5axbjel354rliyce4