Improvement of Aminopeptidase Activity of Dizinc(II) Complexes by Increasing Substrate Accessibility

Md. Jamil Hossain, Akinobu Wada, Yasuhiro Igarashi, Kei-ichiro Aimono, Keisuke Suzuki, Katsuya Tone, Hiroshi Sakiyama
2011 International Journal of Inorganic Chemistry  
A new dizinc(II) complex, [Zn2(bhmp)(MeCO2)2]BPh4 [(bhmp)−: 2,6-bis[bis(2-hydroxyethyl)aminomethyl]-4-methylphenolate anion], performs aminopeptidase activity to hydrolyze L-leucine-p-nitroanilide. As compared with a related dizinc(II) complex [Zn2(bomp)(MeCO2)2]BPh4 [(bomp)−: 2,6-bis[bis(2-methoxyethyl)aminomethyl]-4-methylphenolate anion], the activity of the present bhmp complex was about 80 times greater than that of the bomp complex. This is mainly because the substrate accessibility was
more » ... accessibility was improved by changing the terminal methoxy groups to hydroxyl groups.
doi:10.1155/2011/395418 fatcat:wct5npggfvgwpbrbamj2jvnteu