A convenient route for synthesis and antimicrobial evaluation of bis (diimino benzothiazolo pyrimido pyrimidines)

Balasaheb D Kalyankar, Prashant N Ubale, Sambhaji P Vartale
2014 Oriental Journal of Chemistry  
Pyrimido pyrimidine and its derivatives are interesting class of nitrogen containing heterocyclic compounds which are widely found in bio-organic and medicinal chemistry with application in drug discovery. Pyrimido [4,5-d] pyrimidines, pyrido [2,3d] pyrimidines are important class of annulated uracils which have biological importance 1 because of their connection with purine pyrimidine system 2 . Some of them exhibit significant biological and pharmacological activities such as antifolate
more » ... as antifolate ABSTRACT Guanidine hydrochloride (1) on treatment with bis(methylthio)methylene malononitrile (2) in N,N-dimethyl formamide (DMF) and catalytic amount of anhydrous potassium carbonate gives diimino pyrimido pyrimidine (3). The later were further reacted with various substituted 2-amino benzothiazoles (4) to gives bis (diimino benzothiazolo pyrimido pyrimidines) (5a-g). All these synthesized compounds were screened for their antimicrobial activity.
doi:10.13005/ojc/300448 fatcat:4asigwgkjrh77jberyphqvzfxm