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Pyrimido pyrimidine and its derivatives are interesting class of nitrogen containing heterocyclic compounds which are widely found in bio-organic and medicinal chemistry with application in drug discovery. Pyrimido [4,5-d] pyrimidines, pyrido [2,3d] pyrimidines are important class of annulated uracils which have biological importance 1 because of their connection with purine pyrimidine system 2 . Some of them exhibit significant biological and pharmacological activities such as antifolatedoi:10.13005/ojc/300448 fatcat:4asigwgkjrh77jberyphqvzfxm