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Jay A Nadel
2016 Respiratory Research  
commentary review reports primary research COPD = chronic obstructive pulmonary disease; EGF(R) = epidermal growth factor (receptor); MAPK = mitogen-activated protein kinase; TGF = transforming growth factor; TNF = tumor necrosis factor. Abstract Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth
more » ... a epidermal growth factor receptor (EGFR) expression and activation, causing goblet-cell metaplasia from Clara cells by a process of cell differentiation. These cells are also believed to be the cells of origin of non-small-cell lung cancer, but this occurs via cell multiplication. The mechanisms that determine which pathway is chosen are critical but largely unknown. Although no effective therapy exists for hypersecretion at present, the EGFR cascade suggests methods for effective therapeutic intervention.
doi:10.1186/rr43 fatcat:uwksdsro3fepzokgzl5g6gtc3m