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Heparinases are critical tools for the studies of highly heterogeneous heparin (HP)/heparan sulfate (HS). However, the exolytic heparinases urgently needed for the sequencing of HP/HS chains are seemingly inaccessible. Herein, a type of exolytic heparinases (exoHepases) was identified from the genomes of different bacteria. These exoHepases share almost no homology with known Hepases and prefer to digest HP rather than HS chains by sequentially releasing unsaturated disaccharides from theirdoi:10.21203/rs.3.rs-54275/v1 fatcat:icjwi6gymramdlec5nl2kzla6y