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COMMENT. Autistic spectrum disorders are characterized by impaired social interaction, restricted interests, and repetitive behaviors. Risk of ASD development in children with TSC is increased with early persistent seizure activity in the left temporal lobe, the brain region responsible for social perception and communication. Interictal epileptiform discharges in the temporal lobe, and cyst-like tubers on MRI may provide markers for ASD in TSC.doi:10.15844/pedneurbriefs-25-4-4 fatcat:oen5ynmd6ndsxovd5o44qeu5fa