PNAS Plus Significance Statements

2018 Proceedings of the National Academy of Sciences of the United States of America  
The critical inquiry of paintings is essentially comparative. This limits the number of artworks that can be investigated by an art expert in reasonable time. The recent availability of large digitized art collections enables a shift in the scale of such analysis through the use of computational methods. Our research shows that simple physics-inspired metrics that are estimated from local spatial ordering patterns in paintings encode crucial information about the artwork. We present numerical
more » ... ales that map well to canonical concepts in art history and reveal a historical and measurable evolutionary trend in visual arts. They also allow us to distinguish different artistic styles and artworks based on the degree of local order in the paintings. (See pp. For influenza virus to release from the infected host cell, controlled viral budding must finalize with membrane scission of the viral envelope. Curiously, influenza carries its own protein, M2, which can sever the membrane of the constricted budding neck. Here we elucidate the physical mechanism of clustering and spatial localization of the M2 scission proteins through a combined computational and experimental approach. Our results provide fundamental insights into how M2 clustering and localization interplay with membrane curvature, membrane lateral stresses, and lipid bilayer phase behavior during viral budding to contribute to virion release. (See pp. E8595-E8603.)
doi:10.1073/pnas.ss11537 fatcat:3ctjfjbmzfcpzlkvr7gb774t6m