HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil

Paula Virginia Michelon Toledo, Denise Siqueira de Carvalho, Luiza Romagnoli, Gustavo Marcinko, Clovis Arns da Cunha, Margely Nunes de Souza, Rodrigo Brindeiro, Flávio de Queiroz-Telles
2010 Brazilian Journal of Infectious Diseases  
Antiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing to treatment failure in patients. Genotyping HIV-1 allows the selection of new drugs after initial drug failure. This study evaluated the genotypic profi le of HIV-1 isolates from treated (drug-experienced) patients in Paraná, Brazil. The prevalence of mutations in reverse
more » ... ations in reverse transcriptase (RT) and protease (PR) genes were assessed. We analyzed 467 genotypes of patients with HIV-1 viral loads above 1,000 copies/mL. Mutations at HIV-1 RT and PR genes and previously used ART regimens were recorded. The most prevalent RT mutations were: . The prevalence of mutations was in line with previous national and international reports, except to nonnucleoside analogue reverse transcriptase inhibitors related mutations, which were more prevalent in this study. Previous exposure to antiretroviral drugs was associated with genotypic resistance to specifi c drugs, leading to treatment failure in HIV patients.
doi:10.1016/s1413-8670(10)70076-3 pmid:20963321 fatcat:6jjl4xbkcnhindicadcpbdbtfy