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Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis
[article]
2020
bioRxiv
pre-print
AbstractThe cerebral microvasculature is essential for preservation of normal cerebral function. Age-related decreases of neurogenesis and cognitive function are accompanied by reduced blood flow and a decline in neural stem cell (NSC) number. Here, we report that metformin administered by tail vein injection enhanced cognition in aged but not young mice in a dose-dependent manner. Further, metformin restored cerebral blood flow and brain vascular density and promoted neurogenic potential of
doi:10.1101/2020.03.25.006767
fatcat:enmerkg4njfqbj7dh4m5z6no7u