Synthesis and Anti-Virus Activity of Some Nucleosides Analogues

Ivanka G. Stankova, Mario F. Simeonov, Vera Maximova, Angel S. Galabov, Evgeny V. Golovinsky
1999 Zeitschrift für Naturforschung C - A Journal of Biosciences  
New 3'-, 5'-, 5-bromo-2'-deoxyuridine (3 a-g) and 3'-, 5'-thymidine (4 a-i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modification on the antiviral activity has been also reported. Three 5-bromo-2'-deoxyuridine derivatives containing glycyl-, glycyl-glycyl-and glycyl-gly-cyl-glycyl-residues (3a, 3b, 3c) showed a strong activity against the
more » ... es virus PsRV and a moderate one vs. HSV-1. The corresponding thymidine analogues were considerably less effective, and only compounds 4d and 4h showed a borderline effect against PsRV
doi:10.1515/znc-1999-1-214 fatcat:shn6z3rnijcsjaplrsf5vsbv3y