CURRENT REVIEW ON DENGUE : LIFE CYCLE OF DENGUE, PATHOPHYSIOLOGY AND DIAGNOSIS

Reddygari Jyothsna Thimma, R Vadivelan, Swati Sharma, Richu Babu
2018 Journal of Pharmaceutical and Scientific Innovation  
Dengue is the major health concern in developing countries. Dengue is mainly caused by four serotypes of dengue virus (DENV). Based on the symptoms dengue is classified into febrile fever, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). It had become endemic to 128 countries that may occur throughout the year. Dengue virus has two life cycles -sylvatic and urban cycle. These both life cycles occur in primates, mosquitoes and humans. This disease is transmitted generally by Aedes
more » ... generally by Aedes species mosquitoes. Aedes aegypti and Aedes albopictus are the primary carriers for the dengue transmission. The majorly used diagnostic assays are serology, virus RNA (RiboNucleic Acid) detection, antigen detection and virus detection. In endemic countries dengue is uncontrollable due to unavailability of vaccines and particular antivirals. Protective measures such as larvicide spraying and wearing suitable clothes to prevent mosquito bites can reduce the diseased population. Government, stakeholders and public health system can contribute for awareness programmes to public in endemic countries. Sanofi Pasteur invented dengvaxia used for 9 to 45 years age people can help to reduce the severity of dengue.
doi:10.7897/2277-4572.07172 fatcat:ssfput63a5b4pl45rya4hef7vi